DISEASES

Disease-gene associations mined from literature

Literature on FLRT2

FLRT2 [ENSP00000332879]

Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.

Synonyms:  FLRT2,  FLRT2p,  hFLRT2,  O43155,  O43155p ...

Linkouts:  STRING  Pharos  UniProt  OMIM