DISEASES

Disease-gene associations mined from literature

Literature on MRE11

MRE11 [ENSP00000325863]

Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase . In telomeres the MRN complex may modulate t-loop formation . ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:9590181,; Belongs to the MRE11/RAD32 family.

Synonyms:  MRE11p,  hMRE11,  A0A024R395,  F5GXT0,  F5H256 ...

Linkouts:  STRING  Pharos  UniProt  OMIM