DISEASES

Disease-gene associations mined from literature

Literature on CABP1

CABP1 [ENSP00000317310]

Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist- induced intracellular calcium signaling . Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels . Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C- terminal domain of CACNA1C, but has an opposite effect on channel function . Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels . Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). ECO:0000250|UniProtKB:Q9JLK7, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941,

Synonyms:  CABP1,  CABP1p,  hCABP1,  C9J8G2,  Q9NZU7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM