DISEASES

Disease-gene associations mined from literature

Literature on SWAP70

SWAP70 [ENSP00000315630]

Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

Synonyms:  SWAP70,  SWAP70p,  hSWAP70,  E7EMB1,  E9PJK8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM