DISEASES

Disease-gene associations mined from literature

Literature on IL17RC

IL17RC [ENSP00000295981]

Interleukin-17 receptor C; Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA . Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA . Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA . Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 . [Isoform 6]: Does not bind IL17A or IL17F. [Isoform 8]: Receptor for both IL17A and IL17F.

Synonyms:  IL17RC,  IL17RCp,  hIL17RC,  A8K3Q5,  B4DI24 ...

Linkouts:  STRING  Pharos  UniProt  OMIM