DISEASES

Disease-gene associations mined from literature

Literature on SPTSSB

SPTSSB [ENSP00000352097]

Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2- SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction.

Synonyms:  SPTSSB,  Q6ZWB5,  Q8NFR3,  Q6ZWB5p,  hQ6ZWB5 ...

Linkouts:  STRING  Pharos  UniProt