DISEASES

Disease-gene associations mined from literature

Literature on TRIB1

TRIB1 [ENSP00000312150]

Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase . The COP1- binding motif is masked by autoinhibitory interactions with the protein kinase domain . Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA . Binds selectively the recognition sequence of CEBPA . Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity . ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797,; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Synonyms:  TRIB1,  TRIB1p,  hTRIB1,  E5RFH4,  Q96RU8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM