DISEASES

Disease-gene associations mined from literature

Literature on CNOT2

CNOT2 [ENSP00000229195]

CCR4-NOT transcription complex subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4- NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754,

Synonyms:  CNOT2,  CNOT2p,  hCNOT2,  A0A024RBD8,  A0A087X050 ...

Linkouts:  STRING  Pharos  UniProt  OMIM