DISEASES

Disease-gene associations mined from literature

Literature on PPP2R2D

PPP2R2D [ENSP00000399970]

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Synonyms:  PPP2R2D,  PPP2R2Dp,  hPPP2R2D,  A0A096LPI9,  A0A0A6YYD6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM