DISEASES

Disease-gene associations mined from literature

Literature on LILRB1

LILRB1 [ENSP00000315997]

Leukocyte immunoglobulin-like receptor subfamily B member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles . Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions . Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide . Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells . Reprograms B cells toward an immune suppressive phenotype . ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:28636952, ECO:0000269|PubMed:29262349,

Synonyms:  LILRB1,  LILRB1p,  hLILRB1,  A0A087WSV6,  A0A087WSX8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM