DISEASES

Disease-gene associations mined from literature

Literature on FBXL15

FBXL15 [ENSP00000224862]

F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Synonyms:  FBXL15,  FBXL15p,  hFBXL15,  A0A0C4DFV0,  Q9H469 ...

Linkouts:  STRING  Pharos  UniProt  OMIM