DISEASES

Disease-gene associations mined from literature

Literature on GNAI3

GNAI3 [ENSP00000358867]

Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels . Stimulates the activity of receptor-regulated K(+) channels . The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division . ; Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Synonyms:  GNAI3,  GNAI3p,  hGNAI3,  P08754,  P08754p ...

Linkouts:  STRING  Pharos  UniProt  OMIM