DISEASES

Disease-gene associations mined from literature

Literature on WDR59

WDR59 [ENSP00000262144]

GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 .

Synonyms:  WDR59,  WDR59p,  hWDR59,  B7Z7V6,  H3BMH3 ...

Linkouts:  STRING  Pharos  UniProt