DISEASES

Disease-gene associations mined from literature

Literature on NDST4

NDST4 [ENSP00000264363]

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity); Belongs to the sulfotransferase 1 family. NDST subfamily.

Synonyms:  NDST4,  NDST4p,  hNDST4,  Q9H3R1,  Q9H3R1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM