DISEASES

Disease-gene associations mined from literature

Literature on SYT10

SYT10 [ENSP00000228567]

Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).

Synonyms:  SYT10,  SYT10p,  hSYT10,  F5GZB8,  Q6XYQ8 ...

Linkouts:  STRING  Pharos  UniProt