Literature on MYSM1
MYSM1 [ENSP00000418734]
Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis and lymphocyte differentiation ; Belongs to the peptidase M67A family. MYSM1 subfamily.
Synonyms: MYSM1, MYSM1p, hMYSM1, Q5VVJ2, Q5VVJ2p ...