DISEASES

Disease-gene associations mined from literature

Literature on ARPIN

ARPIN [ENSP00000350075]

Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Synonyms:  ARPIN,  H0YL03,  H0YMP5,  Q7Z6K5,  H0YL03p ...

Linkouts:  STRING  Pharos  UniProt