DISEASES

Disease-gene associations mined from literature

Literature on ASF1A

ASF1A [ENSP00000229595]

Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198,; Belongs to the ASF1 family.

Synonyms:  ASF1A,  ASF1Ap,  hASF1A,  Q9Y294,  Q9Y294p ...

Linkouts:  STRING  Pharos  UniProt  OMIM