DISEASES

Disease-gene associations mined from literature

Literature on PLA2G15

PLA2G15 [ENSP00000219345]

Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity . Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso- phospholipid . Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2- dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity . ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:11790796, ECO:0000269|PubMed:20410020, ECO:0000269|PubMed:23958596,

Synonyms:  PLA2G15,  PLA2G15p,  hPLA2G15,  B4DJW4,  B4DPU0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM