DISEASES

Disease-gene associations mined from literature

Literature on NEK6

NEK6 [ENSP00000362702]

Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression . Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis . Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 . Phosphorylates KIF11 to promote mitotic spindle formation . Involved in G2/M phase cell cycle arrest induced by DNA damage . Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence . ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783,

Synonyms:  NEK6,  NEK6p,  hNEK6,  A0A024R8A6,  Q5TBG1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM