DISEASES

Disease-gene associations mined from literature

Literature on CENPU

CENPU [ENSP00000281453]

Centromere protein U; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. ; Belongs to the CENP-U/AME1 family.

Synonyms:  CENPU,  D6R9S4,  Q09GN1,  Q71F23,  D6R9S4p ...

Linkouts:  STRING  Pharos  UniProt