Literature on SMPDL3B
SMPDL3B [ENSP00000363001]
Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase . Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown . Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). ; Belongs to the acid sphingomyelinase family.
Synonyms: SMPDL3B, SMPDL3Bp, hSMPDL3B, F8VWW8, F8VXS3 ...