DISEASES

Disease-gene associations mined from literature

Literature on FCN1

FCN1 [ENSP00000360871]

Ficolin-1; Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 . Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Synonyms:  FCN1,  FCN1p,  hFCN1,  A0A087WVE2,  O00602 ...

Linkouts:  STRING  Pharos  UniProt  OMIM