DISEASES

Disease-gene associations mined from literature

Literature on PRICKLE1

PRICKLE1 [ENSP00000345064]

Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.

Synonyms:  PRICKLE1,  A0A024R0W7,  A0A1W2PPC7,  F8VUG8,  F8W1J1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM