DISEASES

Disease-gene associations mined from literature

Literature on RTN4RL2

RTN4RL2 [ENSP00000335397]

Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton .

Synonyms:  RTN4RL2,  RTN4RL2p,  hRTN4RL2,  G3V1D7,  Q86UN3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM