DISEASES

Disease-gene associations mined from literature

Literature on SKA3

SKA3 [ENSP00000319417]

Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner . In the complex, it mediates the microtubule- stimulated oligomerization . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules ; Belongs to the SKA3 family.

Synonyms:  SKA3,  SKA3p,  hSKA3,  F5GWG1,  F5H8H7 ...

Linkouts:  STRING  Pharos  UniProt