DISEASES

Disease-gene associations mined from literature

Literature on NDC80

NDC80 [ENSP00000261597]

Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules . Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules . ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108,; Belongs to the NDC80/HEC1 family.

Synonyms:  NDC80p,  hNDC80,  A8K031,  I3L0P0,  I3L4G3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM