DISEASES

Disease-gene associations mined from literature

Literature on RNF144B

RNF144B [ENSP00000259939]

E3 ubiquitin-protein ligase RNF144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin- dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Synonyms:  RNF144B,  RNF144Bp,  hRNF144B,  Q7Z419,  Q7Z419p ...

Linkouts:  STRING  Pharos  UniProt