DISEASES

Disease-gene associations mined from literature

Literature on COLEC12

COLEC12 [ENSP00000383115]

Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541,

Synonyms:  COLEC12,  COLEC12p,  hCOLEC12,  Q5KU26,  Q5KU26p ...

Linkouts:  STRING  Pharos  UniProt  OMIM