DISEASES

Disease-gene associations mined from literature

Literature on SCARA5

SCARA5 [ENSP00000346990]

Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1); Belongs to the SCARA5 family.

Synonyms:  SCARA5,  SCARA5p,  hSCARA5,  Q6ZMJ2,  Q6ZMJ2p ...

Linkouts:  STRING  Pharos  UniProt  OMIM