DISEASES

Disease-gene associations mined from literature

Literature on H2AC14

H2AC14 [ENSP00000328484]

Histone H2A type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  H2AC14,  H2AC14p,  hH2AC14,  HIST1H2AJ,  Q99878 ...

Linkouts:  STRING  Pharos  UniProt  OMIM