DISEASES

Disease-gene associations mined from literature

Literature on SIDT2

SIDT2 [ENSP00000314023]

SID1 transmembrane family member 2; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded . Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis . Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:27846365,

Synonyms:  SIDT2,  SIDT2p,  hSIDT2,  C9JBG5,  E9PMC3 ...

Linkouts:  STRING  Pharos  UniProt