DISEASES

Disease-gene associations mined from literature

Literature on MYO1G

MYO1G [ENSP00000258787]

Minor histocompatibility antigen HA-2; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.

Synonyms:  MYO1G,  MYO1Gp,  hMYO1G,  A0A3B3IU30,  B0I1T2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM