DISEASES

Disease-gene associations mined from literature

Literature on HSPB6

HSPB6 [ENSP00000004982]

Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. ECO:0000269|PubMed:20843828, ECO:0000269|PubMed:22427880, ECO:0000305,

Synonyms:  HSPB6,  HSPB6p,  hHSPB6,  A0A1X7SC65,  HEL55 ...

Linkouts:  STRING  Pharos  UniProt  OMIM