DISEASES

Disease-gene associations mined from literature

Literature on PRR5L

PRR5L [ENSP00000368144]

Proline-rich protein 5-like; Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton . Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration . Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM- CSF, in response to stress . Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress ; Belongs to the PROTOR family.

Synonyms:  PRR5L,  PRR5Lp,  hPRR5L,  E9PIU0,  E9PJV4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM