DISEASES

Disease-gene associations mined from literature

Literature on C4BPA

C4BPA [ENSP00000356037]

C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Synonyms:  C4BPA,  C4BPAp,  hC4BPA,  A6PVY5,  F2Z2V7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM