DISEASES

Disease-gene associations mined from literature

Literature on ANAPC5

ANAPC5 [ENSP00000261819]

Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Synonyms:  ANAPC5,  ANAPC5p,  hANAPC5,  F5GY68,  F5GZ05 ...

Linkouts:  STRING  Pharos  UniProt  OMIM