DISEASES

Disease-gene associations mined from literature

Literature on PPP1R15A

PPP1R15A [ENSP00000200453]

Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196,

Synonyms:  PPP1R15A,  M0QXL1,  O75807,  M0QXL1p,  hM0QXL1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM