DISEASES

Disease-gene associations mined from literature

Literature on PRMT8

PRMT8 [ENSP00000372067]

Protein arginine N-methyltransferase 8; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS . ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585,

Synonyms:  PRMT8,  PRMT8p,  hPRMT8,  Q9NR22,  Q9NR22p ...

Linkouts:  STRING  Pharos  UniProt  OMIM