DISEASES

Disease-gene associations mined from literature

Literature on HIVEP1

HIVEP1 [ENSP00000368698]

Zinc finger protein 40; This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Synonyms:  HIVEP1,  HIVEP1p,  hHIVEP1,  A0A0D9SFF3,  C9J2N3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM