DISEASES

Disease-gene associations mined from literature

Literature on IFIT5

IFIT5 [ENSP00000360860]

Interferon-induced protein with tetratricopeptide repeats 5; Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments . Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non- self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner . Also recognizes and selectively binds AT-rich dsDNA . Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 . ECO:0000269|PubMed:23774268, ECO:0000269|PubMed:25092312,; Belongs to the IFIT family.

Synonyms:  IFIT5,  IFIT5p,  hIFIT5,  Q13325,  Q13325p ...

Linkouts:  STRING  Pharos  UniProt