DISEASES

Disease-gene associations mined from literature

Literature on BUB3

BUB3 [ENSP00000357858]

Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. ; Belongs to the WD repeat BUB3 family.

Synonyms:  BUB3,  BUB3p,  hBUB3,  A0A140VJF3,  J3QSX4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM