DISEASES

Disease-gene associations mined from literature

Literature on C11orf80

C11orf80 [ENSP00000354227]

Type 2 DNA topoisomerase 6 subunit B-like; [Isoform 3]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.

Synonyms:  C11orf80,  A0A0A0MRH1,  A0A140TA08,  A0A2R8Y5A2,  A0A2U3TZP7 ...

Linkouts:  STRING  Pharos  UniProt