Literature on ITM2C
ITM2C [ENSP00000322730]
Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Synonyms: ITM2C, ITM2Cp, hITM2C, A0A024R466, B8ZZM6 ...