DISEASES

Disease-gene associations mined from literature

Literature on TOLLIP

TOLLIP [ENSP00000314733]

Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity . Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP- dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates .

Synonyms:  TOLLIP,  E7EN89,  E9PNS3,  E9PP67,  E9PQ25 ...

Linkouts:  STRING  Pharos  UniProt  OMIM