DISEASES

Disease-gene associations mined from literature

Literature on PAOX

PAOX [ENSP00000278060]

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion . Can also oxidize N(1)- acetylspermidine to putrescine. Substrate specificity: N(1)- acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs .

Synonyms:  PAOX,  Q6QHF9,  Q6QHF9p,  hQ6QHF9,  1.5.3.13 ...

Linkouts:  STRING  Pharos  UniProt  OMIM