DISEASES

Disease-gene associations mined from literature

Literature on MARCHF4

MARCHF4 [ENSP00000273067]

E3 ubiquitin-protein ligase MARCHF4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Synonyms:  MARCHF4,  MARCHF4p,  hMARCHF4,  MARCH4,  Q9P2E8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM