DISEASES

Disease-gene associations mined from literature

Literature on LPCAT2

LPCAT2 [ENSP00000262134]

Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn- glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.

Synonyms:  LPCAT2,  LPCAT2p,  hLPCAT2,  H3BU68,  Q7L5N7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM