DISEASES

Disease-gene associations mined from literature

Literature on SARAF

SARAF [ENSP00000256255]

Store-operated calcium entry-associated regulatory factor; Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

Synonyms:  SARAF,  A0A140VK59,  E5RFJ9,  E5RHW0,  E5RJG8 ...

Linkouts:  STRING  Pharos  UniProt