DISEASES

Disease-gene associations mined from literature

Literature on RIOX2

RIOX2 [ENSP00000328251]

Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935,; Belongs to the ROX family. MINA53 subfamily.

Synonyms:  RIOX2,  RIOX2p,  hRIOX2,  D6RCB6,  H0Y8K4 ...

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